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Epithelial Presenilin-1 drives colorectal tumor growth by controlling EGFR-COX2 signalling

ABSTRACT: We analyzed the role of Presenilin1 (Psen1) during intestinal tumorigenesis. With this aim, transcriptome comparison of mouse tumor organoids derived from Psen1flox Apcmin/+ and Psen1ΔIEC Apcmin/+ mice was performed. The analysis revealed alteration in the EGFR pathway and in arachidonic acid metabolism.

ORGANISM(S): Mus musculus

PROVIDER: GSE212898 | GEO | 2022/09/13

REPOSITORIES: GEO

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