Expression data of cHL cell lines after KLF4 activation

ABSTRACT: Characteristic extinguishing of B-cell phenotype in cHL is believed to be a result of transcription factor network deregulation due to the overexpression of repressor proteins ID2 and ABF-1. KLF4 is a versatile transcription factor, participating in regulation of differentiation processes in various tissues. Epigenetic silencing of KLF4 in cHL hints that KLF4 is involved in the complex mechanism of extinguishing of B-cell phenotype in cHL. To clarify this issue we investigated transcriptome changes, induced by KLF4 activation in two cHL cell lines KM-H2 and L428.

ORGANISM(S): Homo sapiens

PROVIDER: GSE21296 | GEO | 2010/10/22

SECONDARY ACCESSION(S): PRJNA126243

REPOSITORIES: GEO