Transcriptomics

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Development of the chicken lateral plate mesoderm and forelimb mesenchyme


ABSTRACT: The lateral plate mesoderm (LPM) is a transient tissue that produces a diverse range of differentiated structures, including the limbs. However, the molecular mechanisms that drive early LPM specification and development are poorly understood. In this study, we utilize single-cell transcriptomics to define the cell-fate decisions directing LPM specification, subdivision, and early initiation of the forelimb mesenchyme in chicken embryos. We establish a transcriptional atlas and global cell-cell signalling interactions in progenitor, transitional and mature cell types throughout the developing forelimb field.

ORGANISM(S): Gallus gallus

PROVIDER: GSE212985 | GEO | 2022/09/13

REPOSITORIES: GEO

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