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Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis [CUT&Tag]

ABSTRACT: To verify that arginine metabolic enzymes are directly regulated by H3K9ac, we established FHs74Int cells and HDAC8-overexpressing FHs74Int cells We then performed gene expression profiling analysis using data obtained from CUT&Tag of 4 different treatment conditions in control or HDAC8 stably overexpressed FHs74Int cells ,which treated with PCI34051 (10 µmol/L for 24 h) or LPS (10 µg/ml for 48 h).

ORGANISM(S): Homo sapiens

PROVIDER: GSE213190 | GEO | 2022/09/16

REPOSITORIES: GEO

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Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis [RNA-seq]

Project description:To determine which signaling pathway may have been affected by HDAC8, we designed NEC mice model with PCI34051 supplementation. We then performed gene expression profiling analysis using data obtained from RNA-seq of intestinal tissues (control group, NEC group, PCI34051+NEC group) treated with PCI34051 (10 mg/kg/d).

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Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

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Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis [PCI34051 study]

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-16 | GSE213191 | GEO

Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

Project description:Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

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Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis [PCI34051 study]

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Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis [CUT&Tag]

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