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Impaired dynamic X-chromosome inactivation maintenance in T lymphocytes is a feature of spontaneous lupus in female mice that is exacerbated in female-biased disease models

ABSTRACT: The molecular basis for the female bias of systemic lupus erythematosus remains unclear. We sought to determine the fidelity of dynamic X-chromosome inactivation maintenance in the pathogenesis of murine models of spontaneous lupus, including the heavily female-biased NZM2328 model.

ORGANISM(S): Mus musculus

PROVIDER: GSE213318 | GEO | 2022/09/20

REPOSITORIES: GEO

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