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Impact of KIF26A loss in human forebrain organoids

ABSTRACT: KIF26A is an unconventional kinesin that lacks motor activity. To characterize its role in brain development, we generated KIF26A knock-out iPSC lines and differentiated forebrain organoids. We performed single cell RNA sequencing at Day 60 and Day 80 to compare between control and KIF26A-deleted organoids at the molecular level, which revealed cell type-specific transcriptional changes in MAPK, MYC and E2F pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE213330 | GEO | 2022/09/20

REPOSITORIES: GEO

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