Transcriptomics

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RNA data of human FOP patients-derived iPSCs treated with ACVR1 R206H mutant-targeting AAVs


ABSTRACT: We found that both A9 (amiR-RH6) and A10 (amiR-RH7)-AAVs significantly decrease osteogenic differentiation of FOP-iPSCs. We also observed that A9 and A10-AAVs treatment changed the ratio of R206H mutant to wildtype of ACVR1 in FOP-iPSCs. To identify off-target effect of A9 or A10-AAVs, we compared RNA expression of FOP-iPSCs treated with control, A9, or A10-AAVs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE213579 | GEO | 2022/09/20

REPOSITORIES: GEO

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