Spatial transcriptomics of human plastic and non-plastic breast cancer subtypes
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ABSTRACT: Cellular plasticity is a hallmark of rare Claudin-low (CL) and metaplastic (MBC) breast cancer subtypes, with a documented overlap whose exact extent is yet unknown, and which are associated to resistance and poor survival. We used spatial transcriptomics to further characterise these plastic subtypes, respectively defined molecularly and histopathologically. We identified 3 putative CL tumours (CL-like) and 4 genomically unstable TNBC samples via molecular analyses, combined with 4 MBCs identified by a breast pathologist.
ORGANISM(S): Homo sapiens
PROVIDER: GSE213688 | GEO | 2023/10/16
REPOSITORIES: GEO
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