Transcriptomics

Dataset Information

0

De novo emergence, existence, and demise of a protein-coding gene in murids [mouse]


ABSTRACT: Genes, principal units of genetic information, vary in complexity and evolutionary history. Less-complex genes (e.g. long non-coding RNA (lncRNA) expressing genes), readily emerge de novo from non-genic sequences and have high evolutionary turnover. Genesis of a gene is facilitated by adoption of functional genic sequences from retrotransposon insertions. However, protein-coding sequences in extant genomes rarely lack any connection to an ancestral protein-coding sequence. Here, we describe remarkable evolution of the murine gene D6Ertd527e and its orthologs in the rodent Muroidea superfamily. The D6Ertd527e emerged in a common ancestor of mice and hamsters as an lncRNA-expressing gene. A major contributing factor was a long terminal repeat (LTR) retrotransposon insertion carrying an oocyte-specific promoter and one of the first exons of the gene. The gene survived as an oocyte-specific lncRNA in several extant rodents while in some others the gene or its expression was lost. In the ancestral lineage of Mus musculus, the gene acquired protein-coding capacity where the bulk of the coding sequence formed through CAG (AGC) trinucleotide repeat expansion and duplications. These events gave rise to a cytoplasmic serine-rich maternal protein, which has no discernable role. Knock-out of D6Ertd527e in mice affects neither fertility nor the maternal transcriptome. While this evolving gene is not showing a notable function in laboratory mice, its documented evolutionary history in Muroidea during the last ~40 million years provides a textbook example of how a several common mutation events can support de novo gene formation, evolution of protein-coding capacity, as well as gene’s demise.

ORGANISM(S): Mus musculus

PROVIDER: GSE213819 | GEO | 2022/10/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-10-31 | GSE213818 | GEO
2017-08-14 | GSE100959 | GEO
2017-08-14 | GSE100958 | GEO
2014-11-20 | E-GEOD-62416 | biostudies-arrayexpress
2020-01-09 | PXD014553 | Pride
2014-01-19 | E-GEOD-43520 | biostudies-arrayexpress
2024-02-14 | GSE237744 | GEO
2012-04-27 | E-GEOD-37132 | biostudies-arrayexpress
2012-07-10 | E-GEOD-39256 | biostudies-arrayexpress
2016-03-24 | E-GEOD-70419 | biostudies-arrayexpress