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Analysis of the role of SMARCB1 in bladder cancer cell line T24 [ATAC-seq]

ABSTRACT: To identify DNA accessibility targets regulated by the SWI/SNF subunit SMARCB1 in bladder cancer, we compared the ATAC-seq signals in T24 cells engineered for SMARCB1 knockout, non-targeting control, or SMARCB1 re-expression following knockout. Analysis of altered DNA accessibility profiles revealed new roles for SMARCB1 in the regulation of gene expression in bladder cancer, and suggested new therapeutic opportunities.

ORGANISM(S): Homo sapiens

PROVIDER: GSE213964 | GEO | 2023/11/17

REPOSITORIES: GEO

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Analysis of the role of SMARCB1 in bladder cancer cell line T24 [ATAC-seq]

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