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Transcriptome profiling of the livers from Mettl3 flox/flox and hepatocyte-specific Mettl3 knockout (HKO) mice

ABSTRACT: The goal of this study is to compare transcriptome profilings of liver from Mettl3 flox/flox and hepatocyte-specific Mettl3 knockout (HKO) mice. Gene ontology analysis showed that the dowregulated genes were associated with monocarboxylic acid metabolic process, small molecule catabolic process, fatty acid metabolic process, cofactor metabolic process, organic acid catabolic process, and lipid biosynthetic process, whereas the upregulated genes were associated with leukocyte migration, cell chemotaxis, leukocyte cell-cell adhesion, positive regulation of cytokine production and defense response to other organism. KEGG pathway analysis showed that the downregulated genes were associated with Steroid hormone biosynthesis, Peroxisome, Chemical carcinogenesis, proteasome, Oxidative phosphorylation and Non-alcoholic fatty liver disease (NAFLD), whereas the upregulated genes were associated with Cell adhesion molecules (CAMs), Staphylococcus aureus infection, Viral protein interaction with cytokine and cytokine receptor, and Chemokine signaling pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE214371 | GEO | 2023/03/12

REPOSITORIES: GEO

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RNA-seq analysis of mRNA profiles in the livers of Wtapflox/flox and hepatocyte-specific Wtap knockout (HKO) mice

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ATAC-seq of liver samples in Mettl3 flox/flox and hepatocyte-specific Mettl3 knockout (HKO) mice

Project description:ATAC-seq of liver samples in Mettl3 flox/flox and hepatocyte-specific Mettl3 knockout (HKO) mice

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Transcriptome profiling of the livers from Mettl3 flox/flox and hepatocyte-specific Mettl3 knockout (HKO) mice

Project description:Transcriptome profiling of the livers from Mettl3 flox/flox and hepatocyte-specific Mettl3 knockout (HKO) mice

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Project description:RNA-seq and ATAC-seq of liver samples in Mettl3 flox/flox and hepatocyte-specific Mettl3 knockout (HKO) mice

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2016-07-03 | E-GEOD-65098 | biostudies-arrayexpress

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