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Effect of Pak4 ablation on transcriptome in liver of fasted mice

ABSTRACT: Hepatic ketogenesis is crucial for energy homeostasis in a fast state, whereas defective ketogenesis is associated with various diseases. We explored the role of PAK4, an oncoprotein, in ketogenesis. To investigate the molecular basis, we carried out RNA-sequencing analysis using littermate WT and hepatocyte-specific Pak4 KO mice in fasted conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE214442 | GEO | 2023/07/31

REPOSITORIES: GEO

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Effect of Pak4 deficiency on transcriptomic profile in eWAT of mice

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Effect of Pak4 ablation on transcriptome in liver of fasted mice

Project description:Effect of Pak4 ablation on transcriptome in liver of fasted mice

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PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer

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