Transcriptomics

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Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease


ABSTRACT: Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by UMOD mutations is characterized by strong interfamilial variability. We generated two mutant Umod knock-in mouse models, harbouring two mutations associated with drastic differences in kidney survival in ADTKD patients. We performed bulk RNA-sequencing of kidney extracts from Umod KI mice at an early (1 month) and advanced (4 months) stage of disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE214491 | GEO | 2022/10/02

REPOSITORIES: GEO

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