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Next Generation Sequencing Facilitates Quantitative Analysis of THP-1 cells under different stimulas.

ABSTRACT: To explore the role of human RNase1 on macrophage polarization, we induced human monocytes (THP-1) to differentiate into uncommitted macrophages and then polarized them to different phenotypes by lipopolysaccharide (LPS)/interferon (IFN)-γ, interleukin (IL)-4, or RNase1 as a stimulus. We then performed gene expression profiling analysis using data obtained from RNA-seq of Nivolumab reponders and non-reponsers.

ORGANISM(S): Homo sapiens

PROVIDER: GSE215012 | GEO | 2023/12/06

REPOSITORIES: GEO

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