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Comparison of Enteral versus Parenteral Feeding in Healthy Human Subjects (Supported by NIH grant GM34695)

ABSTRACT: Literature suggests that the route of feeding may impact the immune system. This study examines changes in gene expression due to route of feeding in healthy volunteers. Healthy volunteers were fed contniuous parenteral diet or continuous enteral diet for 72 hours

ORGANISM(S): Homo sapiens

PROVIDER: GSE21534 | GEO | 2010/04/29

SECONDARY ACCESSION(S): PRJNA125941

REPOSITORIES: GEO

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Comparison of Enteral versus Parenteral Feeding in Healthy Human Subjects (Supported by NIH grant GM34695)

Project description:Literature suggests that the route of feeding may impact the immune system. This study examines changes in gene expression due to route of feeding in healthy volunteers. Healthy volunteers were fed continuous parenteral diet or continuous enteral diet for 72 hours Blood samples were collected prior to feeding and 72 hours after feeding. Monocytes were purified using Rosette Sep protocol. We used microarrays to identifiy genes with significantly changed expression.

2010-05-27 | E-GEOD-21534 | biostudies-arrayexpress

Neonatal antibotic prophylaxis modulates intestinal immunity and prevents necrotizing enterocolitis in preterm neonates

Project description:Caesarean-delivered preterm pigs were fed 3 d of parenteral nutrition followed by 2 d of enteral formula feeding. Antibiotics (n=11) or control saline (n=13) were given twice daily from birth to tissue collection at d 5. NEC-lesions and intestinal structure, function, microbiology and immunity markers were recorded. We used Affymetrix microarrays to investigate gene expression in intestinal tissues of preterm piglets treated with antibiotics or control saline. Twenty-four preterm piglets were delivered by caesarean section on day 105 of gestation from two healthy sows. All piglets were initially provided with parenteral nutrition via a vascular catheter, combined with small amounts of minimal enteral nutrition. On day three, all parenteral nutrition was stopped and total enteral nutrition was given through an oro-gastric feeding tube. Piglets were allocated into controls ( n=13) and an intervention group receiving oral and systemic broad-spectrum antibiotics ( n=11). To assure high systemic and intra luminal MIC values antibiotics were given both orally and intramuscularly. All antibiotics were given directly after feeding with an oral bolus and control pigs were given corresponding amounts of saline. On day five, all piglets were euthanized, and small intestinal tissue collected.

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Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures

Project description:Parenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient’s medical conditions. Despite numerous animal studies and clinical observations, the molecular mechanisms driving IFALD remain largely unknown. The present study was set up to elucidate the mechanisms underlying IFALD. For this purpose, human liver spheroid co-cultures were treated with TPN mixture followed by RNA sequencing analysis. It was found that prolonged exposure to TPN substantially changes the transcriptome profile of liver spheroids and affects multiple metabolic and signaling pathways contributing to liver injury.

2024-05-03 | GSE264357 | GEO

Neonatal antibotic prophylaxis modulates intestinal immunity and prevents necrotizing enterocolitis in preterm neonates

2013-08-21 | GSE48125 | GEO

Homo sapiens

Project description:Comparison of Enteral versus Parenteral Feeding in Healthy Human Subjects (Supported by NIH grant GM34695)

| PRJNA125941 | ENA

E-GEOD-21534

Project description:Comparison of Enteral versus Parenteral Feeding in Healthy Human Subjects (Supported by NIH grant GM34695)

2015-09-15 | E-GEOD-21534 | ExpressionAtlas

Early enteral and parenteral nutrition in patients with nutritional risk after gastrointestinal surgery

Project description:Interventions: EEN:Early enteral nutrition;Control:Total parenteral nutrition Primary outcome(s): Albumin,Pre-albumin,body mass index and so on Study Design: Randomized parallel controlled trial

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RNA-sequencing identifies novel transcriptomic signatures in parenteral nutrition-associated liver disease

Project description:RNA-sequencing in liver from control and parenteral nutrition-associated liver disease (PNALD) rats

2022-06-01 | GSE171007 | GEO

Transcriptomic analysis of early IFALD in preterm piglets receiving parenteral nutrition

Project description:Preterm Yorkshire piglets were provided parenteral nutrition for 14 days and developed cholestasis and histologic liver injury. Bottle-fed age-matched controls were provided sow milk replacer every 2-3 hours for 14 days.

2023-08-02 | GSE234108 | GEO

Amniotic fluid and necrotizing enterocolitis in preterm pigs

Project description:Preterm neonates are susceptible to gastrointestinal (GI) disorders such as necrotizing enterocolitis (NEC). Maternal milk, and especially colostrum, protects against NEC via growth promoting, immunomodulatory and antimicrobial factors. The fetal enteral diet, amniotic fluid (AF), contains similar bioactive components and we hypothesized that postnatal AF administration would reduce inflammatory responses and NEC in preterm neonates. Thirty preterm pigs (92% gestation) were delivered by caesarean section and fed total parental nutrition (TPN) for 48 h followed by enteral porcine colostrum (COLOS, n=7), infant formula (FORM, n=13) or formula + porcine AF (AF, n=10). Using a previously validated model of NEC in preterm pigs, we determined the structural, functional, microbiological and immunological responses to AF when administered prior to and after introduction of a suboptimal enteral formula diet. Keywords: Healthy versus inflammed tissues in relation to necrotizing enterocolitis

2010-03-01 | GSE13515 | GEO

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