Targeting MUC1-C sensitizes colorectal cancer cells to BRAF inhibitor

ABSTRACT: BRAF mutant colorectal cancer has a poor prognosis and gets resistant to BRAF inhibitors quickly. This study aims to clarify the mechanism of resistance to BRAFi. We found MCU1-C is overexpressed in BRAF mutant colorectal cancer and targeting MUC1-C genetically and pharmacologically sensitized Colorectal cancer cells to BRAF inhibitor. This finding suggests that MUC1-C could be a new therapeutic target for BRAF mutant colorectal cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE215849 | GEO | 2022/11/30

REPOSITORIES: GEO