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Race-specific patterns of epigenetic aging and age-associated differential methylation in normal rectal biopsies: Implications for the biology of aging and its relationship to rectal cancer

ABSTRACT: Approximately 90% of colorectal cancer (CRC) develop over the age of 50, highlighting the im-portant role of aging in CRC risk. African Americans (AAs) shoulder a greater CRC burden than European Americans (EA), and are more likely to develop CRC at a younger age. The effects of aging in AA and EA normal rectal tissue have yet to be defined. Here, we performed epige-nome-wide DNA methylation analysis in the first, large-scale biracial cohort of normal rectum (n=140 samples)

ORGANISM(S): Homo sapiens

PROVIDER: GSE216024 | GEO | 2022/12/23

REPOSITORIES: GEO

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