Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet [ChIP-Seq]

ABSTRACT: The environment influences the metabolism and behavior of progeny by working through the germline to introduce spontaneous genetic mutations as well as a variety of epigenetic changes, including alterations in DNA methylation status, changes in non-coding RNAs (ncRNAs) and the post-translational modification of histones. Therefore, we used ChIP-seq to ask whether maternal HSD exposure induce alterations in post-translational modification of H3K27 and H3K9.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE216075 | GEO | 2022/10/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-19 | GSE216076 | GEO

Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet [RNA-Seq]

Project description:To investigate the differentially expressed gene in head of adult flies which ancestors exposed in high sugar diet

2022-10-18 | GSE215756 | GEO

Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet

Project description:Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet

| PRJNA892031 | ENA

Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet [ChIP-Seq]

Project description:Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet [ChIP-Seq]

| PRJNA892038 | ENA

Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet [RNA-Seq]

Project description:Histone methylation mediates transgenerational modulations of sweet perception by high sugar diet [RNA-Seq]

| PRJNA890569 | ENA

Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing.

Project description:Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, closely related gustatory receptor (Gr) genes, Gr5a, Gr61a, and Gr64a-Gr64f, of which three have been proposed to mediate sweet taste [3-6]. However, expression and function of several of these putative sugar Gr genes are not known. Here, we present a comprehensive expression and functional analysis using Gr(LEXA/GAL4) alleles that were generated through homologous recombination. We show that sugar Gr genes are expressed in a combinatorial manner to yield at least eight sets of sweet-sensing neurons. Behavioral investigations show that most sugar Gr mutations affect taste responses to only a small number of sugars and that effective detection of most sugars is dependent on more than one Gr gene. Surprisingly, Gr64a, one of three Gr genes previously proposed to play a major role in sweet taste [3, 4], is not expressed in labellar taste neurons, and Gr64a mutant flies exhibit normal sugar responses elicited from the labellum. Our analysis provides a molecular rationale for distinct tuning profiles of sweet taste neurons, and it favors a model whereby all sugar Grs contribute to sweet taste. Furthermore, expression in olfactory organs and the brain implies novel roles for sugar Gr genes in olfaction and internal nutrient sensing, respectively. Thus, sugar receptors may contribute to feeding behavior via multiple sensory systems.

| S-EPMC4711800 | biostudies-literature

Cascaded Amplitude Modulations in Sound Texture Perception.

Project description:Sound textures, such as crackling fire or chirping crickets, represent a broad class of sounds defined by their homogeneous temporal structure. It has been suggested that the perception of texture is mediated by time-averaged summary statistics measured from early auditory representations. In this study, we investigated the perception of sound textures that contain rhythmic structure, specifically second-order amplitude modulations that arise from the interaction of different modulation rates, previously described as "beating" in the envelope-frequency domain. We developed an auditory texture model that utilizes a cascade of modulation filterbanks that capture the structure of simple rhythmic patterns. The model was examined in a series of psychophysical listening experiments using synthetic sound textures-stimuli generated using time-averaged statistics measured from real-world textures. In a texture identification task, our results indicated that second-order amplitude modulation sensitivity enhanced recognition. Next, we examined the contribution of the second-order modulation analysis in a preference task, where the proposed auditory texture model was preferred over a range of model deviants that lacked second-order modulation rate sensitivity. Lastly, the discriminability of textures that included second-order amplitude modulations appeared to be perceived using a time-averaging process. Overall, our results demonstrate that the inclusion of second-order modulation analysis generates improvements in the perceived quality of synthetic textures compared to the first-order modulation analysis considered in previous approaches.

| S-EPMC5601004 | biostudies-literature

SUGAR-Seq enables simultaneous detection of glycans, epitopes and the transcriptome in single cells [ATAC-seq]

Project description:Multi-modal single cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular differentiation states, but does not allow for simultaneous integration of critical post-translational modification data. Here, we describe SUrface-protein Glycan And RNA-seq (SUGAR-seq); a method that enables detection and analysis of N-linked glycosylation, extracellular epitopes and the transcriptome at the single cell level. Integrated SUGAR-seq and glycoproteome analysis identified tumor infiltrating T cells with unique surface glycan properties that report their epigenetic and functional state.

2021-02-22 | GSE166324 | GEO

SUGAR-Seq enables simultaneous detection of glycans, epitopes and the transcriptome in single cells [3'RNA-seq]

2021-02-22 | GSE166323 | GEO

SUGAR-Seq enables simultaneous detection of glycans, epitopes and the transcriptome in single cells [TIL scRNA-seq]

2021-02-22 | GSE166326 | GEO