Global knock out of Sirt3 gene in Alzheimer’s transgenic mice with amyloid pathology
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ABSTRACT: We have previously demonstrated that Sirt3 gene deletion, a model for metabolic syndrome, leads to brain mitochondrial dysfunction and neuroinflammation. We also reported that silencing of Sirt3 gene in APP/PS1 mice results in exacerbation of insulin resistance, neuroinflammation and β amyloid plaque deposition. To further understand how metabolic syndrome and amyloid pathology interact, we performed RNA-seq analysis of the brain samples from wild type, Sirt3-/- , APP/PS1 and APP/PS1/Sirt3-/- mice.
ORGANISM(S): Mus musculus
PROVIDER: GSE216081 | GEO | 2022/10/24
REPOSITORIES: GEO
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