Transcriptomics

Dataset Information

0

Global knock out of Sirt3 gene in Alzheimer’s transgenic mice with amyloid pathology


ABSTRACT: We have previously demonstrated that Sirt3 gene deletion, a model for metabolic syndrome, leads to brain mitochondrial dysfunction and neuroinflammation. We also reported that silencing of Sirt3 gene in APP/PS1 mice results in exacerbation of insulin resistance, neuroinflammation and β amyloid plaque deposition. To further understand how metabolic syndrome and amyloid pathology interact, we performed RNA-seq analysis of the brain samples from wild type, Sirt3-/- , APP/PS1 and APP/PS1/Sirt3-/- mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE216081 | GEO | 2022/10/24

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-01-17 | GSE249611 | GEO
2019-11-25 | GSE136861 | GEO
2022-06-25 | GSE206629 | GEO
2014-04-30 | E-MTAB-2121 | biostudies-arrayexpress
2018-02-23 | GSE104249 | GEO
2011-03-15 | E-GEOD-27309 | biostudies-arrayexpress
2021-01-01 | GSE109479 | GEO
2024-09-30 | GSE235179 | GEO
2022-08-02 | GSE180746 | GEO
2020-02-29 | GSE146133 | GEO