Transcriptomics

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Expression data for cultured NCI-H1299 parental and spheroid cells as well as their derived xenograft models


ABSTRACT: Current approaches to the preclinical investigation for novel cancer therapies rely heavily on the use of traditional cancer cell lines maintained in serum-containing conditions. The discrepancy between promising preclinical efficacy and clinical outcome of most novel anticancer agents emphasizes a need for developing predictive preclinical models that preserve the integrity of original patient tumors, including cancer stem cell (CSC) compartment. In this study, we isolate and characterize CSCs from a non-small cell lung cancer cell line, NCI-H1299, by selectively propagating the cells in a stem-cell culture condition. Isolated CSCs proliferated as nonadherent spheroids, displayed capacity to differentiate and self-renew and exhibited higher tumorigenic potential compared to the parental cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE21612 | GEO | 2010/07/01

SECONDARY ACCESSION(S): PRJNA126987

REPOSITORIES: GEO

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