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Genome-wide localization of SMAD2/3 and JUN family protein and epigenetic landscapes in human breast cell line treated with or without TGF-β.

ABSTRACT: The non-receptor tyrosine kinase SRC is overexpressed in various human cancers, however, transcriptional mechanisms underlying SRC expression is poorly understood. In this study, we found that transforming growth factor-β (TGF-β), which is abundantly secreted in tumor microenvironment, upregulates SRC protein and mRNA expression. To clarify the molecular mechanisms underlying TGF-β-induced SRC expression, we analyzed the genome-wide localization of SMAD2/3 and JUN family protein and epigenetic landscapes in human breast cell lines. These results showed that a novel TGF-β-responsive enhancer, which localizes at intragenic region of SRC, is activated via TGF-β/SMAD pathway and upregulates SRC expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE216432 | GEO | 2023/07/14

REPOSITORIES: GEO

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The TGF-β/SMAD pathway upregulates SRC

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HNF4A-binding sites in HepG2 hepatoblastoma cells treated with TGF-beta

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