An effective therapy by co-targeting c-Myc and Bcl-2 for resistant acute myeloid leukemia.
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ABSTRACT: We showed that genetically double-knockdown of c-Myc/Bcl-2 synergistically killed AML cells and inhibited the growth of AML cells in vivo. Mechanically, co-targeting c-Myc/Bcl-2 reciprocally abrogated over-proliferation and apoptosis resistance via synergistically impairing mitochondrial biogenesis.
ORGANISM(S): Homo sapiens
PROVIDER: GSE216977 | GEO | 2022/11/03
REPOSITORIES: GEO
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