Methylation profiling

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A genome-wide DNA methylation-based classifier differentiates intrahepatic cholangiocarcinomas from hepatic metastases of pancreatic ductal adenocarcinoma


ABSTRACT: Differentiating intrahepatic cholangiocarcinomas (iCCA) from hepatic metastases of pancreatic ductal adenocarcinoma (PAAD) is difficult. We hypothesized that DNA-methylation based machine-learning algorithms may be able to perform this task. We assembled genome-wide DNA-methylation data for iCCA, PAAD, and normal bile from publicly available sources. We used an internal cohort consisting of 72 samples to test our classifier.

ORGANISM(S): Homo sapiens

PROVIDER: GSE217384 | GEO | 2023/06/05

REPOSITORIES: GEO

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