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Single-nucleus transcriptomic profiling of multiple organs from rhesus macaque model with SARS-CoV-2 infection

ABSTRACT: Here we profiled about 77000 single-nucleus transcriptomes of lung, liver, kidney, and cerebral cortex from rhesus macaques infected with SARS-CoV-2. Our work of multi-organ single-nucleus transcriptomic survey of SARS-CoV-2 infected animal model expanded our understanding of disease features and antiviral immune defects caused by the novel coronavirus at cellular and molecular level, which may facilitate the development of potential therapeutic intervention for COVID-19.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE217483 | GEO | 2022/12/22

REPOSITORIES: GEO

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