Single cell transcriptomic analysis of cortical cell type composition underlying diabetes-associated cognitive decline
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ABSTRACT: Type 2 diabetes (T2D) is associated with increased risk of cognitive decline although the precise underlying pathogenesis remains obscure. Based on the single-cell RNA sequencing approach applied to the cerebral cortex of a T2D mouse model (db/db), we identified novel regulatory mechanisms underlying diabetes-associated cognitive deficits. Our data adds detail to the highly complex neurovascular pathology associated with T2D and highlights key cell-specific deficits in mitochondrial bioenergetics linked to neuroinflammation, which underlie T2D-linked cognitive impairment.
ORGANISM(S): Mus musculus
PROVIDER: GSE217665 | GEO | 2023/06/26
REPOSITORIES: GEO
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