A low-carbohydrate diet induces hepatic insulin resistance and metabolic-associated fatty liver disease

ABSTRACT: We demonstrate that the ketogenic diet a low carbohydrate diet can induce fibrosis and NASH regardless of body weight loss compared to high-fat diet (HFD) fed mice. KD-fed mice develop severe hepatic injury, inflammation, and steatosis. In addition, KD increases IL-6-JNK signaling and aggravates diet induced-glucose intolerance and hepatic insulin resistance compared to HFD. Notably, pharmacological inhibition of IL-6 and JNK reverses KD‐induced glucose intolerance and restores insulin sensitivity.

ORGANISM(S): Mus musculus

PROVIDER: GSE218025 | GEO | 2023/01/31

REPOSITORIES: GEO