Transcriptomics

Dataset Information

0

A low-carbohydrate diet induces hepatic insulin resistance and metabolic-associated fatty liver disease


ABSTRACT: We demonstrate that the ketogenic diet a low carbohydrate diet can induce fibrosis and NASH regardless of body weight loss compared to high-fat diet (HFD) fed mice. KD-fed mice develop severe hepatic injury, inflammation, and steatosis. In addition, KD increases IL-6-JNK signaling and aggravates diet induced-glucose intolerance and hepatic insulin resistance compared to HFD. Notably, pharmacological inhibition of IL-6 and JNK reverses KD‐induced glucose intolerance and restores insulin sensitivity.

ORGANISM(S): Mus musculus

PROVIDER: GSE218025 | GEO | 2023/01/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2011-12-05 | E-GEOD-31647 | biostudies-arrayexpress
2021-08-14 | GSE182071 | GEO
2022-02-16 | PXD024308 | Pride
2021-10-15 | GSE167046 | GEO
2014-11-05 | E-GEOD-60349 | biostudies-arrayexpress
2024-03-14 | GSE261185 | GEO
2015-05-18 | E-GEOD-58952 | biostudies-arrayexpress
2021-06-30 | GSE171107 | GEO
2023-10-14 | GSE245301 | GEO
2022-02-17 | PXD027332 | Pride