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Ginkgolide B administration improves health span and lifespan in aged mice

ABSTRACT: Ginkgolide B (GB) is a small molecule from Ginkgo biloba and implicates the reduction of certain aging-related morbidities; however, whether GB improves overall healthspan and longevity remains unknown. By single-nucleus RNA sequencing (snRNA-seq), we revealed that GB partially restored the aging-related dysregulation in cell-type composition, intracellular signaling pathways, and cell-cell communication in skeletal muscle. Notably, GB reduced the quantity of aging-induced novel Runx1+ type 2B myonuclei, which are particularly associated with an apoptotic burden and aging-related signatures.

ORGANISM(S): Mus musculus

PROVIDER: GSE218027 | GEO | 2024/10/31

REPOSITORIES: GEO

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