Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice [bulk RNA-Seq]

ABSTRACT: To investigate the effect of Grin2a (a schizophrenia risk gene) and Grin2b (an autism spectrum disorder risk gene) loss of function on brain transcriptome. We performed unbiased transcriptomic profiling (bulk RNAseq analysis) in 5 brain regions and at four postnatal ages in Grin2a and Grin2b mutant mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE218551 | GEO | 2023/08/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice [snRNA-seq]

Project description:To identify which brain cell types are contributing to the bulk transcriptomic changes in Grin2a mutant mice, we performed single-nucleus RNAseq (snRNAseq) in Grin2a heterozygous and homozygous mutants and their wild-type littermates at 4 and 12 weeks of age.

2023-08-31 | GSE218572 | GEO

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

Project description:Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

| PRJNA904331 | ENA

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice [snRNA-seq]

Project description:Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice [snRNA-seq]

| PRJNA904338 | ENA

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice [bulk RNA-Seq]

Project description:Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice [bulk RNA-Seq]

| PRJNA904305 | ENA

Temporal dysregulation of cortical gene expression in the isolation-reared Wistar rat

Project description:The critical sequence of molecular, neurotransmission and synaptic disruptions that underpin the emergence of psychiatric disorders like schizophrenia remain to be established with progress only likely using animal models that capture key features of such disorders. Gene expression was assessed in social control and isolation reared rats at 4 increasing postnatal ages to relate gene expression dysregulation to behavioural and endophenotype emergence. We prepared cDNA from brain tissue samples of the medial prefrontal cortex from socially reared Wistar rats (Soc) and matching isolation reared cohorts (Iso) at postnatal day (P) 30, 40, 60 and 80.

2010-06-16 | E-GEOD-19653 | biostudies-arrayexpress

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-08-31 | GSE218573 | GEO

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions (hippocampus LNDBB).

Project description:Genetic association studies provide evidence for a substantial polygenic component to schizophrenia, although the neurobiological mechanisms underlying the disorder remain largely undefined. Building on recent studies supporting a role for developmentally regulated epigenetic variation in the molecular etiology of schizophrenia, this study aimed to identify epigenetic variation associated with both a diagnosis of schizophrenia and elevated polygenic risk burden for the disease across multiple brain regions. Genome-wide DNA methylation was quantified in 262 post-mortem brain samples, representing tissue from four brain regions (prefrontal cortex, striatum, hippocampus and cerebellum) from 41 schizophrenia patients and 47 controls. We identified multiple disease-associated and polygenic risk score-associated differentially methylated positions and regions, many residing in the vicinity of genes previously implicated in schizophrenia including NCAM1, SYNPO, GBP4, PRDM9, GADD45B and DISC1. Our study represents the first analysis of epigenetic variation associated with schizophrenia across multiple brain regions and highlights the utility of polygenic risk scores for identifying molecular pathways associated with etiological variation in complex disease.

2016-11-10 | GSE89703 | GEO

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions (cerebellum DBCBB).

2016-11-10 | GSE89702 | GEO

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions (striatum LNDBB).

2016-11-10 | GSE89706 | GEO

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions (striatum DBCBB).

2016-11-10 | GSE89705 | GEO