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Co-option of the transcription factor SALL1 in mole ovotestis formation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Talpa occidentalis

PROVIDER: GSE219025 | GEO | 2022/11/29

REPOSITORIES: GEO

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Co-option of the transcription factor SALL1 in mole ovotestis formation [4C]

Project description:Changes in gene expression represent an important source for phenotypical innovation. Yet, how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing comparative analyses of epigenetic and transcriptional data in mole and mouse, we identified SALL1 as a co-opted gene for the formation of testicular tissue in mole ovotestes. Chromosome conformation capture analyses highlight a striking conservation of the 3D organization at the SALL1 locus, but a prominent evolutionary turnover of enhancer elements. Interspecies reporter assays support the capability of mole-specific enhancers to activate transcription in urogenital tissues. Through overexpression experiments in transgenic mice, we further demonstrate the capability of SALL1 to induce the ectopic gene expression programs that are a signature of mole ovotestes. Our results highlight the co-option of gene expression, through changes in enhancer activity, as a prominent mechanism for the evolution of traits.

2022-11-22 | GSE218437 | GEO

Co-option of the transcription factor SALL1 in mole ovotestis formation [RNA-seq]

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Co-option of the transcription factor SALL1 in mole ovotestis formation [ChIP-seq]

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Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes.

Project description:Changes in gene expression represent an important source of phenotypic innovation. Yet how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing integrative analyses of epigenetic and transcriptional data in mole and mouse, we identified the co-option of SALL1 expression in mole ovotestes formation. Chromosome conformation capture analyses highlight a striking conservation of the 3D organization at the SALL1 locus, but an evolutionary divergence of enhancer activity. Interspecies reporter assays support the capability of mole-specific enhancers to activate transcription in urogenital tissues. Through overexpression experiments in transgenic mice, we further demonstrate the capability of SALL1 to induce kidney-related gene programs, which are a signature of mole ovotestes. Our results highlight the co-option of gene expression, through changes in enhancer activity, as a plausible mechanism for the evolution of traits.

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Sall1 co-operated with Six2 to actively maintain nephron progenitors in the embryonic kidney

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Co-option of neutrophil fates by tissue environments

Project description:This SuperSeries is composed of the SubSeries listed below.

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A general transcription co-factor, Smad3, potentiates master transcription factor mediated cell identity conversions

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-11-02 | GSE85178 | GEO

Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing.

Project description:The ratites are a distinctive clade of flightless birds, typified by the emu and ostrich that have acquired a range of unique anatomical characteristics since diverging from basal Aves at least 100 million years ago. The emu possesses a vestigial wing with a single digit and greatly reduced forelimb musculature. However, the embryological basis of wing reduction and other anatomical changes associated with loss of flight are unclear. Here we report a previously unknown co-option of the cardiac transcription factor Nkx2.5 to the forelimb in the emu embryo, but not in ostrich, or chicken and zebra finch, which have fully developed wings. Nkx2.5 is expressed in emu limb bud mesenchyme and maturing wing muscle, and mis-expression of Nkx2.5 throughout the limb bud in chick results in wing reductions. We propose that Nkx2.5 functions to inhibit early limb bud expansion and later muscle growth during development of the vestigial emu wing.The transcription factor Nkx2.5 is essential for heart development. Here, the authors identify a previously unknown expression domain for Nkx2.5 in the emu wing and explore its role in diminished wing bud development in the flightless emu, compared with three other birds that have functional wings.

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Large scale transposon co-option in the Caenorhabditis germline regulatory network

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-26 | GSE192540 | GEO

Transcription (co)factor and miRNA regulatory landscape of EMT

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-05 | GSE115376 | GEO