Transcriptomics

Dataset Information

0

Infection induces tissue resident memory NK cells that safeguard tissue


ABSTRACT: Tissue health is dictated by the capacity to respond to perturbations and then return to a homeostatic state. Thus, mechanisms that initiate, maintain and regulate immune responses in tissues are essential. The adaptive immune system has been ascribed a principal role in these responses, with memory and tissue-residency being cardinal features of immune protection in tissues. Whether there is a corresponding role for innate cells is unknown. Here we identify a population of innate lymphocytes that we term tissue-resident memory-like natural killer (NKRM) cells. In response to murine cytomegalovirus infection, we show that circulating NK cells are recruited to the salivary glands where they form NKRM cells, a long-lived tissue-resident population that prevents autoimmunity and safeguards organ function. Thus, NK cells develop adaptive-like features, including long-term residency in nonlymphoid tissues, to modulate inflammation, restore immune equilibrium and preserve tissue health. Modulating the functions of NKRM cells may provide new strategies to treat inflammatory and autoimmune diseases.

ORGANISM(S): Mus musculus

PROVIDER: GSE219243 | GEO | 2023/02/13

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-02-13 | GSE222613 | GEO
2024-01-01 | GSE250334 | GEO
2022-02-04 | GSE195930 | GEO
2022-04-09 | GSE200319 | GEO
2023-08-23 | GSE235702 | GEO
2023-11-05 | GSE222454 | GEO
2021-05-17 | GSE155208 | GEO
2018-02-01 | GSE109060 | GEO
2022-05-24 | GSE198611 | GEO
2024-06-14 | GSE240441 | GEO