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Single cell mRNA sequencing on esophageal and lingual cells

ABSTRACT: In this study, we uncovered through single cell RNA sequencing (scRNA-seq) of mouse esophagus epithelium a population of taste buds clustered in the cervical segment of the esophagus. We compared this taste bud population to their lingual counterpart. We concluded that these taste buds have the same cellular composition than the ones from the tongue. State-of-the-art transcriptional regulatory network analysis allowed the identification of specific transcription factors associated to the differentiation of immature progenitors into the three different taste bud cell types in the tongue and the esophagus.

ORGANISM(S): Mus musculus

PROVIDER: GSE220065 | GEO | 2023/03/09

REPOSITORIES: GEO

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mRNA sequencing of epithelial cells from the esophagus and tongue

Project description:In this study, we used RNA sequencing to characterize a new population of taste buds found in the esophagus and compared them to their lingual counterpart. We concluded that esophageal taste buds share many markers with lingual taste buds althoug they seem to express less taste receptors in average.

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