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Collective signalling drives rapid jumping between cell states

ABSTRACT: A continuous single cell transcriptomic time course of Dictyostelium discoideum early development.

ORGANISM(S): Dictyostelium discoideum

PROVIDER: GSE220242 | GEO | 2023/11/07

REPOSITORIES: GEO

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Collective signalling drives rapid jumping between cell states.

Project description:Development can proceed in 'fits and starts', with rapid transitions between cell states involving concerted transcriptome-wide changes in gene expression. However, it is not clear how these transitions are regulated in complex cell populations, in which cells receive multiple inputs. We address this issue using Dictyostelium cells undergoing development in their physiological niche. A continuous single cell transcriptomics time series identifies a sharp 'jump' in global gene expression marking functionally different cell states. By simultaneously imaging the physiological dynamics of transcription and signalling, we show the jump coincides with the onset of collective oscillations of cAMP. Optogenetic control of cAMP pulses shows that different jump genes respond to distinct dynamic features of signalling. Late jump gene expression changes are almost completely dependent on cAMP, whereas transcript changes at the onset of the jump require additional input. The coupling of collective signalling with gene expression is a potentially powerful strategy to drive robust cell state transitions in heterogeneous signalling environments. Based on the context of the jump, we also conclude that sharp gene expression transitions may not be sufficient for commitment.

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Collective signalling drives rapid jumping between cell states

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Cell and molecular transitions during efficient dedifferentiation: testing forG- mutant

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Differential Expression upon infection with Salmonella typhimurium (t2)

Project description:Dictyostelium discoideum is a professional phagocyte and it uses phagocytosis as a way to get food. However, there are a number of bacteria that subvert this professional phagocyte. In this study we investigated whether Salmonella typhimurium is also pathogenic for D. discoideum.

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