Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TET2 guards against unchecked BATF3-induced CAR T cell expansion [ATAC-seq]

ABSTRACT: Comparing genome accessibility profiles (ATACseq) of TET2 deficent hyper-proliferative CAR T cells and unedited CAR T cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE220257 | GEO | 2022/12/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

TET2 guards against unchecked BATF3-induced CAR T cell expansion [RNA-seq]

Project description:Comparing transcriptional profiles of TET2 deficent hyper-proliferative CAR T cells and unedited CAR T cells

2022-12-30 | GSE220258 | GEO

TET2 guards against unchecked BATF3-induced CAR T cell expansion.

Project description:Further advances in cell engineering are needed to increase the efficacy of chimeric antigen receptor (CAR) and other T cell-based therapies1-5. As T cell differentiation and functional states are associated with distinct epigenetic profiles6,7, we hypothesized that epigenetic programming may provide a means to improve CAR T cell performance. Targeting the gene that encodes the epigenetic regulator ten-eleven translocation 2 (TET2)8 presents an interesting opportunity as its loss may enhance T cell memory9,10, albeit not cause malignancy9,11,12. Here we show that disruption of TET2 enhances T cell-mediated tumour rejection in leukaemia and prostate cancer models. However, loss of TET2 also enables antigen-independent CAR T cell clonal expansions that may eventually result in prominent systemic tissue infiltration. These clonal proliferations require biallelic TET2 disruption and sustained expression of the AP-1 factor BATF3 to drive a MYC-dependent proliferative program. This proliferative state is associated with reduced effector function that differs from both canonical T cell memory13,14 and exhaustion15,16 states, and is prone to the acquisition of secondary somatic mutations, establishing TET2 as a guardian against BATF3-induced CAR T cell proliferation and ensuing genomic instability. Our findings illustrate the potential of epigenetic programming to enhance T cell immunity but highlight the risk of unleashing unchecked proliferative responses.

| S-EPMC10511001 | biostudies-literature

TET2 guards against unchecked BATF3-induced CAR T cell expansion

Project description:TET2 guards against unchecked BATF3-induced CAR T cell expansion

| PRJNA909303 | ENA

TET2 guards against unchecked BATF3-induced CAR T cell expansion [ATAC-seq]

Project description:TET2 guards against unchecked BATF3-induced CAR T cell expansion [ATAC-seq]

| PRJNA909309 | ENA

TET2 guards against unchecked BATF3-induced CAR T cell expansion [RNA-seq]

Project description:TET2 guards against unchecked BATF3-induced CAR T cell expansion [RNA-seq]

| PRJNA909310 | ENA

TET2 guards against unchecked BATF3-induced CAR T cell expansion

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-30 | GSE220259 | GEO

car

Project description:Drosophila melanogaster car, carnation, is differentially expressed in 11 experiment(s);

| FBgn0000257 | ExpressionAtlas

car

Project description:Drosophila melanogaster car, carnation, is expressed in 4 baseline experiment(s);

| FBgn0000257 | ExpressionAtlas

ATACSeq of TET2-mutant human neutrophils

Project description:ATACSeq of TET2-mutant human neutrophils

| PRJNA882414 | ENA

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [ATAC-Seq]

Project description:Comparing genome accessibility profiles (ATACseq) of WT and SUV39H1-edited CAR T cells

2023-10-27 | GSE245186 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data