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RNA-seq of murine proliferating neural stem and progenitor cells from Kat7-deleted mouse fetuses

ABSTRACT: Tissue-specific deletion of the gene encoding the histone acetyltransferase Kat7 (Hbo1) in the developing mouse central nervous system using cre-recombinase expression driven by regulatory sequences of the nestin locus (NesCre transgene) resulted in defective cerebral cortex development, a complete failure of neural stem cells to give rise to neurons and oligodendrocytes during in vitro differentiation, and a failure to express the neuronal differentiation program. Proliferating neural stem and progenitor cells (NPSCs) were isolated from Kat7-deleted and Kat7-intact 14.5 day embryonic mouse fetuses.

ORGANISM(S): Mus musculus

PROVIDER: GSE220498 | GEO | 2022/12/09

REPOSITORIES: GEO

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