Transcriptomics

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Gene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors


ABSTRACT: Histone deacetylases (HDACs) regulate gene expression. Inhibition of class I HDACs has been shown to inhibit cancer cell growth. Largazole, a new potent HDAC inhibitor, shows strong antitumor activity, presumably by modulating transcription of cancer relevant genes. We used microarray analysis of human HCT116 colorectal carcinoma cell line to determine the gene expression profile after largazole treatment in comparison with other HDAC inhibitors (FK228 and SAHA). The goal was to identify regulated genes that can be linked to the antiproliferative effects of these HDAC inhibitors in HCT116 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE22061 | GEO | 2010/08/28

SECONDARY ACCESSION(S): PRJNA128969

REPOSITORIES: GEO

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