Transcriptomics

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NLRC5 is a transcriptional regulator of MHC class I genes


ABSTRACT: NLRC5 is a member of the NLR family of proteins. The observation that NLRC5 is found in the nucleus prompted us to perform a gene array to identify putative target genes of NLRC5. We generated Jurkat T cell lines that stably express either the wild-type or mutant forms of NLRC5 harboring mutations in the nucleotide binding domain (NBD): Walker A (deficient in nucleotide binding), Walker B (deficient in nucleotide hydrolysis), and the combined Walker AB, carrying both mutations. Site-directed mutagenesis was used to create the NLRC5 NBD mutants: Walker A (K234A), Walker B (E311Q), and Walker AB (both mutations).

ORGANISM(S): Homo sapiens

PROVIDER: GSE22064 | GEO | 2010/06/30

SECONDARY ACCESSION(S): PRJNA127483

REPOSITORIES: GEO

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