Transcriptomics

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Abnormal Immune Programming in Neutrophils of Cystic Fibrosis


ABSTRACT: This study performed single-cell RNA sequencing (scRNA-seq) analyses on peripheral blood neutrophils from cystic fibrosis (CF) patients and healthy controls (HC) in their native state and LPS-activated state. Differences in global gene transcription were interrogated and compared. Results demonstrate that CFTR loss of function in CF neutrophils led to abnormal immune programming, exemplified by precocious priming at their native state, and abnormal immune response to LPS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE220658 | GEO | 2023/11/09

REPOSITORIES: GEO

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