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Transcriptomic profiling reveals differential cellular response of copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta

ABSTRACT: Concerns about the potential risks to human health due nanoparticulate pollution have been emerging. However, the risks to sensitive populations, such as pregnant individuals and their unborn children are poorly characterised. With increasing evidence of environmental particles passing the placenta, their potential adverse effects of on pregnancy and fetal development need to be assessed. Here, we investigated the impact of copper oxide (CuO) and polystyrene (PS) nanoparticle exposure on gene expression in ex vivo perfused human placental tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE220756 | GEO | 2023/10/01

REPOSITORIES: GEO

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Transcriptomic profiling reveals differential cellular response of copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta

Project description:Transcriptomic profiling reveals differential cellular response of copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta

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Oral ingestion of polystyrene nanoplastics causes memory impairment and neuroinflammation by microglial uptake

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Deciphering the Links: Fragmented Polystyrene as a Driver of Skin Inflammation

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Project description:The release of plastics into the environment has been identified as an important issue for some time. Recent publications have suggested that the degradation of plastic materials will result in the release of nano-sized plastic particles to the environment. Nanoparticle tracking analysis was applied to characterise the formation of nanoplastics during the degradation of a polystyrene (PS) disposable coffee cup lid. The results clearly show an increase in the formation of nanoplastics over time. After 56 days' exposure the concentration of nanoplastics in the PS sample was 1.26 × 10(8) particles/ml (average particles size 224 nm) compared to 0.41 × 10(8) particles/ml in the control.

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Marker gene/pathway discovery for polystyrene particle toxicity in zebrafish larvae

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Oral ingestion of polystyrene nanoplastics causes memory impairment and neuroinflammation by microglial uptake

Project description:Oral ingestion of polystyrene nanoplastics causes memory impairment and neuroinflammation by microglial uptake

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