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Global transcriptomic profiling of nitric oxide-mediated neuronal death

ABSTRACT: Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive oxygen species resulting in deregulation and disruption of cellular homeostasis. Although multiple roles for NO has been reported in neuronal death signaling, existent data fail to provide a holistic description of how nitrergic pathobiology elicits neuronal injury. Here we provide a comprehensive description of mechanisms contributing to NO-induced neuronal injury by global transcriptomic profiling.

ORGANISM(S): Mus musculus

PROVIDER: GSE22087 | GEO | 2013/01/23

SECONDARY ACCESSION(S): PRJNA128937

REPOSITORIES: GEO

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Global transcriptomic profiling of nitric oxide-mediated neuronal death

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