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Bovine blastocyst like structures derived from stem cell cultures

ABSTRACT: Understanding blastocyst formation and implantation is critical for improving farm animal reproduction but is hampered by a limited supply of embryos. We developed an efficient method to generate bovine blastocyst-like structures (termed blastoids) via the assembly of trophoblast stem cells and expanded potential stem cells. Bovine blastoids resemble blastocysts in morphology, cell composition, single-cell transcriptomes, and represent an accessible in vitro model for studying bovine embryogenesis.

ORGANISM(S): Bos taurus

PROVIDER: GSE221248 | GEO | 2023/05/16

REPOSITORIES: GEO

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