Analysis of the roles of AP4 and p53 downstream of c-MYC activation in breast cancer cells.

ABSTRACT: Deregulated expression of the c-MYC oncogene induces unscheduled DNA replication, DNA damage, and activation of the p53 tumor suppressor. The AP4 transcription factor is a direct c-MYC target gene involved in cell proliferation, epithelial-mesenchymal transition, and stemness, as well as suppression of DNA damage and senescence. Here, we analyzed the role of AP4 and p53 downstream of c-MYC activation using a CRISPR/Cas9-approach in MCF-7 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE221265 | GEO | 2023/03/01

REPOSITORIES: GEO