Spatiotemporal local and abscopal cell death and immune responses to histotripsy focused ultrasound tumor ablation
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ABSTRACT: Histotripsy is a novel focused ultrasound tumor ablation modality with potent immunostimulatory effects. To measure the spatiotemporal kinetics of local and abscopal responses to histotripsy, C57BL/6 mice bearing bilateral flank B16 melanoma or Hepa1-6 hepatocellular carcinoma tumors were treated with unilateral sham or partial histotripsy. Treated and Controltralateral untreated (abscopal) tumors were analyzed using multicolor immunofluorescence, digital spatial profiling, RNA sequencing (RNASeq), and flow cytometry.
ORGANISM(S): Mus musculus
PROVIDER: GSE221448 | GEO | 2023/01/12
REPOSITORIES: GEO
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