Transcriptomics

Dataset Information

0

Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia


ABSTRACT: We identified novel nicotinamide-based FLT3 inhibitors ( HSN748) that specifically target FLT3-ITD at sub-nanomolar concentrations and are effective against drug-resistant secondary mutations. In the current study, we evaluated these compounds’ antileukemic activity against FLT3-ITD and gatekeeper mutations in drug-resistant AML, relapsed/refractory AMLs with FLT3 mutations

ORGANISM(S): Homo sapiens

PROVIDER: GSE221459 | GEO | 2024/06/15

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-12-07 | MSV000090855 | MassIVE
2017-01-30 | GSE81420 | GEO
2017-01-30 | GSE81421 | GEO
2015-07-03 | E-GEOD-64862 | biostudies-arrayexpress
2015-07-03 | E-GEOD-64864 | biostudies-arrayexpress
2015-07-03 | E-GEOD-64934 | biostudies-arrayexpress
2015-07-03 | E-GEOD-64873 | biostudies-arrayexpress
2015-11-20 | E-GEOD-75200 | biostudies-arrayexpress
2015-11-20 | GSE75200 | GEO
2015-07-03 | GSE64864 | GEO