Transcriptomics

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Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia


ABSTRACT: We identified novel nicotinamide-based FLT3 inhibitors ( HSN748) that specifically target FLT3-ITD at sub-nanomolar concentrations and are effective against drug-resistant secondary mutations. In the current study, we evaluated these compounds’ antileukemic activity against FLT3-ITD and gatekeeper mutations in drug-resistant AML, relapsed/refractory AMLs with FLT3 mutations

ORGANISM(S): Homo sapiens

PROVIDER: GSE221459 | GEO | 2024/06/15

REPOSITORIES: GEO

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