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Functional studies of TP63-affected ESCC tumor immune microenvironment

ABSTRACT: Our preliminary data from unbiased analyses of both ESCC patient samples and cell lines identified interferon-γ (IFN-γ) signaling pathway as the most significantly enriched pathways suppressed by TP63. To validate the activation of IFN pathways and the immune responses upon silencing of TP63, we utilized immune-competent mice to conduct allograft experiments. To analyze the effect of TP63 on ESCC tumor microenvironment, resected tumors were then collected to perform scRNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE221938 | GEO | 2024/02/29

REPOSITORIES: GEO

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