Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [ChIP-Seq]

ABSTRACT: Genome-wide maps of H3K4me3 and H3K27me3 status in bat fibroblasts and induced pluripotent bat stem cells.

ORGANISM(S): Rhinolophus ferrumequinum

PROVIDER: GSE221962 | GEO | 2023/02/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [ATAC-Seq]

Project description:Genome-wide maps of chromatin state in induced pluripotent bat stem cells and fibroblasts

2023-02-27 | GSE221960 | GEO

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [RRBS]

Project description:Genome-wide methylation state of bat fibroblasts induced pluripotent bat stem cells

2023-02-27 | GSE221964 | GEO

Molecular characterization of bat embryonic fibroblasts, induced pluripotent stem cells and their differentiated progeny [RNA-Seq]

Project description:Gene expression studies in bat fibroblasts, pluripotent stem cells, and their differentiated progeny.

2023-02-27 | GSE221963 | GEO

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells

Project description:Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells

| PRJNA916938 | ENA

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [RRBS]

Project description:Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [RRBS]

| PRJNA916943 | ENA

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [ATAC-Seq]

Project description:Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [ATAC-Seq]

| PRJNA916937 | ENA

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [ChIP-Seq]

Project description:Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells [ChIP-Seq]

| PRJNA916941 | ENA

Molecular characterization of bat embryonic fibroblasts and induced pluripotent stem cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-27 | GSE221965 | GEO

Abortive infection of bat fibroblasts with SARS-CoV-2

Project description:Bats are tolerant to highly pathogenic viruses such as Marburg, Ebola, and Nipah, suggesting the presence of a unique immune tolerance toward viral infection. Here, we compared SARS-CoV-2 infection of human and bat (Rhinolophus ferrumequinum) pluripotent cells and fibroblasts. Since bat cells do not express an ACE2 receptor that allows virus infection, we transduced the human ACE2 receptor into the cells and found that transduced cells can be infected with SARS-CoV-2. Compared to human ESCs-hA, infected bat iPSCs-hA produced about a 100-fold lower level of infectious virus and displayed lower toxicity. In contrast, bat fibroblasts (BEF-hA) produced no infectious virus while being infectable and synthesizing viral RNA and proteins, suggesting abortive infection. Indeed, electron microscopy failed to detect virus-like particles in infected bat fibroblasts in contrast to bat iPSCs or human cells, consistent with the latter producing infectious viruses. This suggests that bat somatic but not pluripotent cells have an effective mechanism to control virus replication. Consistent with previous results by others, we find that bat cells have a constitutively activated innate immune system, which might limit SARS-CoV-2 infection compared to human cells.

2024-10-15 | GSE274964 | GEO

Molecular characterization of bat embryonic fibroblasts, induced pluripotent stem cells and their differentiated progeny [RNA-Seq]

Project description:Molecular characterization of bat embryonic fibroblasts, induced pluripotent stem cells and their differentiated progeny [RNA-Seq]

| PRJNA916942 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data