Evaluation of safety and immuno-efficacy of a next generation live attenuated yellow fever vaccine in cynomolgus macaques
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ABSTRACT: 36 male NHPs were randomized into groups of nine to receive subcutaneous injection in the deltoid muscle region of the upper arm with a single commercial dose of Stamaril (4 LogCCID50) or YF-VAX (6 LogCCID50), or 4 or 5 LogCCID50 vYF at WSL stage. Nine months after vaccination, NHPs along with six additional unvaccinated controls were challenged by a single sub-cutaneous injection of 3.0 LogCCID50 wild-type YFV Asibi strain in the scapula region. Blood samples were obtained before vaccination (baseline) and at various time points after vaccination, and before and after challenge.
ORGANISM(S): Macaca fascicularis
PROVIDER: GSE222229 | GEO | 2023/01/06
REPOSITORIES: GEO
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