Transcriptomics

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Genomic Glucocorticoid Action in Embryonic Mouse Neural Stem Cells


ABSTRACT: The goal of this study was to measure genome-wide expression in primary mouse neural stem/progenitor cell (NSPC) cultures to determine if SOX2 ablation alters the transcriptomic response which occurs following glucocorticoid receptor activation by the synthetic glucocorticoid, Dexamethasone. Neurosphere cultures of SOX2 knock out (KO) NSPCs and control non-deleted wild-type (WT) NSPCs (C57BL/6) derived from the fetal telencephalon were established at postnatal day zero (P0).

ORGANISM(S): Mus musculus

PROVIDER: GSE222392 | GEO | 2023/01/11

REPOSITORIES: GEO

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