Transcriptomics

Dataset Information

0

Patch-seq of human patient-derived diffuse midline glioma xenografts


ABSTRACT: Treatment-resistance of lethal high-grade brain tumors including H3K27M diffuse midline gliomas is thought to arise in part from transcriptional and electrophysiological heterogeneity. These phenotypes are readily studied in isolation using single-cell RNA-seq and whole-cell patch clamping, respectively, but their simultaneous capture is now possible by aspirating a cell's contents into a patch pipet after electrophysiology recordings using a method called 'patch-seq'. Here, we adapt this method to characterize the gene expression programs and functional responses of patient-derived glioma xenografts to neuronal firing at single-cell resolution.

ORGANISM(S): Homo sapiens

PROVIDER: GSE222398 | GEO | 2023/03/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA921869 | ENA
2024-02-28 | GSE245674 | GEO
2022-01-28 | GSE160088 | GEO
| PRJNA776146 | ENA
2016-01-25 | E-MTAB-4092 | biostudies-arrayexpress
2020-09-08 | GSE118099 | GEO
2020-01-25 | GSE144216 | GEO
2021-08-08 | GSE181631 | GEO
2021-08-08 | GSE181630 | GEO
2021-08-08 | GSE181633 | GEO