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Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [hypothalamus]

ABSTRACT: The aim of this study was to determine the impact of early life stress on the motivation for a palatable nutritional reward in two mouse strains. Our data showed that MS associated with unpredictable chronic mild stress in lactating dams exacerbated motivation for a palatable food reward (sweetened milk) in both males and females C3H/HeN mice. Interestingly, no effect of MS was reported on motivation in C57Bl/6J mice strain. The transcriptomic analysis revealed that exacerbated motivation in MS C3H/HeN male mice was associated with marked changes in gene expressions in the NAc, whereas no significant changes were reported in PFC or hypothalamus.

ORGANISM(S): Mus musculus

PROVIDER: GSE222777 | GEO | 2023/07/24

REPOSITORIES: GEO

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Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [nucleus accumbens]

Project description:The aim of this study was to determine the impact of early life stress on the motivation for a palatable nutritional reward in two mouse strains. Our data showed that MS associated with unpredictable chronic mild stress in lactating dams exacerbated motivation for a palatable food reward (sweetened milk) in both males and females C3H/HeN mice. Interestingly, no effect of MS was reported on motivation in C57Bl/6J mice strain. The transcriptomic analysis revealed that exacerbated motivation in MS C3H/HeN male mice was associated with marked changes in gene expressions in the NAc, whereas no significant changes were reported in PFC or hypothalamus.

2023-07-24 | GSE222779 | GEO

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [medial prefrontal cortex]

2023-07-24 | GSE222780 | GEO

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation

Project description:Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation

| PRJNA923354 | ENA

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [hypothalamus]

Project description:Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [hypothalamus]

| PRJNA923351 | ENA

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [nucleus accumbens]

Project description:Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [nucleus accumbens]

| PRJNA923357 | ENA

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [medial prefrontal cortex]

Project description:Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [medial prefrontal cortex]

| PRJNA923358 | ENA

Gut microbes affect the motivation for food reward during obesity

Project description:Gut microbes and food reward motivation

| PRJEB52720 | ENA

Citrobacter rodentium triggers exaggerated mucosal responses in mice developing severe intestinal disease

Project description:Citrobacter rodentium is commonly used to elucidate mucosal responses to infection in mice developing mild disease (e.g. C57BL/6), while little is known about host responses to infection in mice developing severe disease (e.g. C3H/HeN). We report that the phyla Bacteroidetes is a minor component of the tissue-associated microbiome in uninfected C3H/HeN mice. Following infection, C. rodentium rapidly and uniformly colonises the C3H/HeN colonic mucosa, which coincides with downregulation of proteins involved in the TCA cycle and oxidative phosphorylation in intestinal epithelial cells (IECs). In contrast, we observed upregulation of DNA replication and DNA damage repair processes, as well as cholesterol biogenesis, import and export, nutritional immunity, IL-22 and INFg responses, and expression of NLRP3, in IECs. Moreover, C. rodentium triggers a staggered cell proliferation response from 3 days post infection, which correlated with a higher abundance of SLC5A9 and reduced abundance of the IEC differentiation markers SLC26A3 and CA4. Uniquely, C. rodentium triggers differential secretion of gel-forming mucins, with the number of goblet cells filled with acidic and neutral mucins dramatically increasing and decreasing, respectively. Together, these results show that despite vigorous responses, C3H/HeN mice succumb to C. rodentium infection, possibly as a result of excessive and disordered mucosal responses.

2020-01-21 | PXD012846 | Pride

Transcriptome analysis in the medial prefrontal cortex of mice exposed to multi-hit early adversity

Project description:We have employed whole genome microarray expression profiling to identify long-term gene expression changes associated with early adversity in male and female C3H/HeN mice

2019-08-04 | GSE116416 | GEO

Chronic stress deficits in reward behaviour co-occur with low nucleus accumbens dopamine activity during reward anticipation specifically

Project description:Whilst reward pathologies e.g., anhedonia and apathy, are major and common in stress-related neuropsychiatric disorders, their neurobiological bases and therefore treatment are poorly understood. Functional imaging studies in humans with reward pathology indicate that attenuated BOLD activity in nucleus accumbens (NAc) occurs during reward anticipation/expectancy but not reinforcement; potentially, this is dopamine (DA) related. In mice, chronic social stress (CSS) leads to reduced reward learning and effortful motivation and, here, DA-sensor fibre photometry was used to investigate whether these behavioural deficits co-occur with altered NAc DA activity during reward anticipation and/or reinforcement. In CSS mice relative to controls: (1) Reduced discriminative learning of the sequence, tone-on + appetitive behaviour = tone-on + sucrose reinforcement, co-occurred with attenuated NAc DA activity throughout tone-on and sucrose reinforcement. (2) Reduced effortful motivation during the sequence, operant behaviour = tone-on + sucrose delivery + tone-off / appetitive behaviour = sucrose reinforcement, co-occurred with attenuated NAc DA activity at tone-on and typical activity at sucrose reinforcement. (3) Reduced effortful motivation during the sequence, operant behaviour = appetitive behaviour + sociosexual reinforcement co-occurred with typical NAc DA activity at female reinforcement. Therefore, in CSS mice attenuated NAc DA activity is specific to reward anticipation and as such potentially causal to deficits in learning and motivation. CSS did not impact on the transcriptome of ventral tegmentum DA neurons, suggesting that its stimulus-specific effects on NAc DA activity originate elsewhere in the neural circuitry of reward processing.

2024-07-31 | GSE268460 | GEO

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