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Glutamine synthetase regulates the alternative metabolism of γ-aminobutyrate in oral squamous cell carcinoma

ABSTRACT: More than 90% of cancer cases in head and neck region are oral squamous cell carcinoma. Recent studies identified several tumor-specific metabolites for the screening or diagnosis of OSCC patients. However, the metabolic reprogramming of OSCC is not well understood. Here, we compared the metabolites between cancerous and paracancerous tissues of OSCC patients and investigated the metabolism of γ-aminobutyrate in OSCC derived cells. Our data revealed that the increase of γ-aminobutyrate was promoted by the synthesis of glutamate beyond the mitochondria, which was regulated by glutamine synthetase. This study is not only benefit for understanding the pathological mechanisms of OSCC, but also has application prospects for the diagnosis and therapy of OSCC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE222879 | GEO | 2023/07/06

REPOSITORIES: GEO

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Cytosolic glutamine synthetase 1;1 knockout effects on rice roots

Project description:Goal of the study is to characterize distinct function(s) of two cytosolic glutamine synthetase (GS) in rice plants. We grew rice lacking GS1;1 and GS1;2 under the ammonium sufficient condition. We harvested roots from the two mutants as well as those of the corresponding control.

2019-04-01 | E-MTAB-6303 | biostudies-arrayexpress

Gene expression of cytosolic glutamine synthetase 1;1 knock-out mutant rice

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2010-03-01 | GSE15122 | GEO

Microarray analysis of gene expression in rice lacking cytosolic glutamine synthetase 1;2

Project description:Goal of the study is to characterize specific function(s) of the cytosolic glutamine synthetase (GS) 1;2 for apical meristem induction in rice plants. To address the issue, we conducted transcript profiling toward basal parts of the knockout mutant lacking GS1;2. We used microarrays conduct transcript profiling of gs1;2 plants. Wild-type samples were used as control.

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Methionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.

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2023-05-10 | PXD037583 | Pride

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2015-10-20 | GSE73840 | GEO

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2022-04-04 | PXD025701 | Pride

Microarray analysis of gene expression in rice lacking cytosolic glutamine synthetase 1;1 and 1;2 grown under the ammonium sufficient condition

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